Why does adverse pregnancy outcome often remain unexplained?
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- There may be poor correlation between maternal indicators of infection and placental findings
- Placental causes of foetal and perinatal death may be clinically silent, e.g. delayed villous maturation or foetal vascular malperfusion (FVM).
- Intrauterine growth restriction has a multifactorial aetiology related to foetal, maternal and placental pathology.